By Rob Chudzik.

Republished with permission of UConn Today.

 

 

Three-dimensional printing has garnered coverage in the popular press for its application in the custom manufacturing of tools and mechanical parts. But six School of Engineering seniors have recently taken the application of the technology into the medical field, using 3-D printing to create body parts.

Under the direction of Anson Ma, assistant professor in the Department of Chemical and Biomolecular Engineering and the Institute of Materials Science, two three-person teams of chemical engineering students were tasked with creating an artificial kidney for their Senior Design Project using 3-D printing technology. 3-D printing is an additive manufacturing method capable of creating complex parts that are otherwise impossible or extremely difficult to produce.

The students participating were: Derek Chhiv, Meaghan Sullivan, Danny Ung, Benjamin Coscia, Guleid Awale, and Ali Rogers. They are one of the first classes of students to partner with a commercial 3-D printing company, ACT Group, to create a prototype.

The challenge the teams set out to tackle is rooted in a very real problem.

The United States Renal Data System reports that, as recently as 2009, End-Stage Renal Disease (ESRD) resulted in over 90,000 deaths. Options for treatment of renal disease are essentially limited to either an organ transplant or dialysis. However, there is a limited supply of transplantable kidneys, with demand far outstripping the supply; and dialysis is expensive and is only a temporary solution.

According to data from the National Kidney Foundation, there are currently nearly 100,000 people awaiting kidney transplants in the United States, yet only 14,000 kidney transplants took place in the country this year. An additional 2,500 new patients are added to the kidney waiting list each month. Faced with these challenges, the two UConn teams set out on a year-long effort to design and develop a prototype of a cost-effective, functional artificial kidney using chemical engineering principles and 3-D printing technology.

“The objective of the design project is to get these students to combine the latest technology and their chemical engineering knowledge, learned over their four years at UConn, to solve a technical problem where we can make a difference,” notes Ma. “Can they push the technology further?”

Guleid Awale, one of the seniors, said the two design teams each took a slightly different approach to the problem. “While the other team utilized techniques such as electrodialysis and forward osmosis in their prototype, our group opted for mainly hollow fiber membrane technology commonly found in traditional hemodialysis treatments.”

Benjamin Coscia ’14 (ENG) explains the hollow fiber membrane technology: “Because 3D printing resolutions are not currently low enough to print a structure which will actually filter blood, the file is of only the shell of the kidney. Hollow fiber membranes will be installed on the inside to do the filtration function. The kidney will then be sealed together using the threads and sealing o-rings. A fluid called dialysate will be circulated on the outside of the membranes, inside of the shell, which will cause flux of components from the blood. A waste stream maintains the person’s ability to urinate. The outside of the shell can be used as a substrate for growth of biological material for ease of integration into the body.”

After undertaking the research and development of the design, the teams designed the prototype using AutoCAD software. Then each team collaborated with UConn technology partner ACT Group of Cromwell, Conn. to select the appropriate polymers, as well as the right printer to use in printing the particular prototype design.

The two teams presented their projects on May 2 at the School of Engineering Senior Design Demonstration Day.

“The biggest challenge in approaching the project was applying the engineering knowledge we’ve gained during our undergraduate years to a more complex biological application,” Awale notes. “This forced us to come out of our comfort zone and rely on our problem-solving skills in order to come up with viable solutions.”

By Jayna Miller

The chemical engineering graduate program at the University of Connecticut is comprised of bright, innovative leaders who are motivated by change and challenge. The program offers the opportunity for students to enhance their skills and develop their potential.

One student who can attest to the merits of this program is Jason White. Jason completed his undergraduate degree at UConn, and decided he wanted to continue his research here after enjoying his undergraduate experience. Throughout his time at UConn, Jason has worked with Dr. Ranjan Srivastava on analyzing biological systems and developing computational tools that deal with human health-related problems. These analyses have implications towards personalized medicine for each patient.

“Our goal is to use computational tools to understand how a disease progresses and to analyze whether treatments for patients are optimal,” Jason says. Genetic algorithms are one such method that Jason employs to develop mathematical models of biological systems from experimental data sets. He anticipates that these models could be used to help personalize medicinal treatments on a patient-by-patient basis. For instance, he created a mathematical model of an oral mucositis system, which can be simulated to help predict the outcome and potential treatment options for patients suffering with this disease.

In addition to his research, Jason has also been involved in a number of campus activities. His favorite was the GK-12 Program sponsored by the National Science Foundation, which allowed him to work once a week with technical high school students.

“I enjoyed the GK-12 experience – it gave me the freedom to develop lessons and projects, but also to continue my research as well,” he says. Through this program, he was able to work with students to build a compost water-heating system, which was presented at Lemelson-MIT’s Eureka Fest. Jason has also helped motivate students to get involved in engineering by tutoring undergraduates from Grasso Tech and by serving as a TA at UConn. In the future, Jason plans to pursue these interests and become a professor, so he can maintain the balance between teaching and his research.

During his time at UConn, Jason has earned a number of accolades for his work, such as a Unilever Scholarship, an Arnold Griffin Scholarship, and an NSF GK-12 Fellowship. He has also published two proceedings in the Journal of Clinical Oncology.