By: Taylor Caron
Professor Yongku Cho of the Chemical and Biomolecular Engineering Department has received a Best of BIOT (biochemical technology) award for his presentation at the American Chemical Society’s 2016 National Meeting.
His presentation was entitled “Engineering Antibody Specificity Through Multi-Dimensional High-Throughput Screens,” and is related to his research on creating a more effective antibody to potentially detect Alzheimer’s disease for which he has received a grant from the National Institute of Health (NIH).
Professor Cho’s work involves developing an antibody which will be more effective at binding to the desired target. More precisely, Professor Cho and his lab are developing an antibody which will be more specific in targeting a particular modification that occurs on the target protein known as the Tau protein. He said that his presentation at ACS was focused on their new technology that enables the precise measurement of the antibody’s ability to specifically bind to the desire target.
“The BIOT Award had to do with describing the technology of quantifying antibody specificity,” he said. “Many researchers have focused on what is called affinity, which has to do with an antibody’s strength of attracting other proteins, but specificity is the degree to which an antibody can isolate a single target. Both of these properties are equally important to make a good quality antibody.”
Professor Cho presented a webinar (an online seminar http://www.acsbiot.org/index.php/2016-best-biot/) in September on this subject on behalf of the ACS. He and his research team are currently applying this knowledge to develop a highly specific and reactive antibody.