By Jayna Miller
Lipids are the basic building blocks of biological membranes – and one of the best materials that nature provides us to entrap materials in nanoscale.
Dr. Mu-Ping Nieh, an associate professor at UConn, is leading a research group investigating the potential of lipid-based nanoparticles for drug delivery. Under certain conditions, lipids can self-assemble into hollow, nanoscale spheres (vesicles), solid nanodiscs, or worm-like nano-ribbons. Depending on the properties of drug molecules, it is possible to insert drugs into these structures to help fight diseases, particularly cancer.
One of the challenges involved in this research is how to determine whether the nanodiscs will target cancer-infected cells rather than healthy cells. Current chemotherapy techniques are often harsh, as many good cells are killed in the process of destroying cancer cells, causing patients to become weak from the treatment. The new treatment method proposed by Dr. Nieh’s research team will recognize and attack infected cells only, and thereby reduce patient discomfort.
Dr. Nieh was recently awarded a National Science Foundation grant in 2012 to design such nano-carriers. “Lipid-based nanodiscs and vesicles have the potential to serve as delivery carriers for therapeutics or diagnostic agents, so the stability of the structure is an important issue,” he said.
By examining the morphology of the nanoparticles, Dr. Nieh hopes to gain a better understanding of how the structure affects the targeting efficacy of the nanoparticles, leading to the design of a stable drug delivery system. His next challenge is to generalize the strategy to manufacture uniform nanoparticles from any lipid system in large quantities.
Dr. 
Kelly Burke joins the Chemical & Biomolecular Engineering Department, and has an appointment in the Polymer Program of the Institute of Materials Science. Dr. Burke, who joins UConn under the Eminent Faculty Initiative, earned her PhD at Case Western Reserve University in 2010 and brings expertise in protein modification strategies, tissue engineering, structure-property relationships of liquid crystals, and biocompatible multifunctional polymeric materials. Dr. Burke was a post-doctoral associate at Tufts University (2010-13), where she received an NIH National Research Service Award Fellowship.
Yongku Cho joins the Chemical & Biomolecular Engineering Department. He received his PhD from the University of Wisconsin – Madison in 2010. Dr. Cho’s research centers on protein engineering, optogenetics, neuroimaging and molecular neurobiology. He was most recently a post-doctoral researcher at the Massachusetts Institute of Technology, where his work involved the molecular engineering of light-activated proteins.
Luyi Sun joins the Chemical & Biomolecular Engineering Department, and has an appointment in the Polymer Program of the Institute of Materials Science. Dr. Sun, who joins UConn under the Eminent Faculty Initiative, received his PhD at the University of Alabama in 2004 and brings expertise in multi-functional nanostructured materials; polymeric materials and new polymer processing development; layered compounds; green science and engineering; hydrates and porous materials for energy storage. He was an assistant professor of chemistry at Texas State University (2009-13) and was a post-doctoral fellow at both Texas A&M and the University of Alabama.
Julia Valla joins the Chemical & Biomolecular Engineering Department with expertise in the design and development of novel catalysts for industrial applications and design of new, emerging technologies and processes for the clean and sustainable energy production. She earned her PhD at Aristotle University of Thessaloniki, Greece in 2005. Dr. Valla was previously an assistant research professor in CMBE and the Center for Clean Energy Engineering and, earlier in her career, a Project Leader for Rive Technology Inc.
Kristina Wagstrom joins the Chemical & Biomolecular Engineering Department as the Northeast Utilities Assistant Professor of Environmental Engineering Education. She brings expertise in sourcing and modeling atmospheric particulates, air pollutants, health impacts of atmospheric particulate matter deposition, and air quality models. Dr. Wagstrom received her PhD from Carnegie Mellon University in 2009. She conducted post-doctoral research at the University of Minnesota (2009-12), and was an AAAS Science and Technology Policy Fellow at the U.S. EPA (2012-13).
