Professor, Associate Dean for Research & Graduate Education
Ph.D., Rutgers University (2002)
Current Research
- Microbial Systems Engineering
- Agriculture Biotechnology
- Environmental Biotechnology
- Microfluidics & BioMEMS
Professional Activities
Chair Elect, 2018: Environmental Division, American Institute of Chemical Engineers
Member: American Chemical Society
Member: American Society for Microbiology
Member: American Society for Engineering Education
Current Research Group
Ph.D. Students | M.S. Students | Undergraduate Students | |
Grant M. Bouchillon Brian Cruz Yi-Syuan Guo Andrea M. Kadilak |
Alycia Fulton | Frederick Bretherton Mitchell Cyr Victoria Drake Elise Gilcher Jake Lewis Genesis Quiles-Galarza Jessica Rehaag Alyson Tacchi Nur Hamideh Cameron Harrington Paige Orlofsky Alyssa Pierne |
Research Statement
Dr. Shor leads the Engineered Microhabitats research group.
OVERVIEW. Microbes important in nature, in medicine, and in industry generally live in complex communities and inhabit intricate, micro-structured habitats. The theme of the Engineered Microhabitats research group is to systematically understand the actions and interactions of microbial communities living in complex micro-habitats. This work has direct applications to biofuel production, environmental biotechnology, and medicine.
MOISTURE REGULATION BY SOIL BACTERIA. Microbial processes may help regulate the rate and extent of water loss from soils. This project aims to better understand the potential of microbes to promote resiliency in terrestrial ecosystems. We are developing a multifunctional in situ platform linking gene expression to overall system function in a physically realistic emulated soil microenvironment. This project will develop novel optogenetic tools to place the genes of soil microbes under the control of light and enable microscale spatiotemporal control of microbial genetic capabilities in situ, and build systems-level understanding of the microbial water-regulating function through pore-scale and root-scale mathematical modeling. Collaborative with Jessica Chau, Yongku Cho, and Dan Gage. Funding: DOE. http://science.energy.gov/~/media/ber/berac/pdf/201510/Anderson_BERAC_Oct_2015.pdf
GREENER AGRICULTURE BIOTECHNOLOGY. Health and productivity of agricultural crops can be dependent on the presence of symbiotic microorganisms to fix nitrogen or protect plant roots from pathogens. This project is investigating the use of naturally-occurring soil protists to act as transport vectors to move beneficial bacteria through soils and improve crop yields while reducing the need for chemical fertilizers and pesticides. UConn collaborator: Dan Gage (http://mcb.uconn.edu/daniel-gage/). Funding: USDA 2016-67013-24412. http://portal.nifa.usda.gov/web/crisprojectpages/1007947-enhanced-transport-of-plant-growth-promoting-rhizobacteria-by-coinoculated-soil-protists.html
MICROENGINEERING THE TERMITE GUT. The lower termite is capable of efficiently converting a mixed lignin-rich feedstock into usable chemicals such as acetate. We hypothesize micro-scale variations in the physical and chemical micro-habitat of the termite gut is essential in supporting the microbial community that achieves this conversion. In this research, we are attempting to produce a replica termite gut micro-bioreactor to better understand the maintenance and regulation of the termite microbiome, and ultimately, to harness it as a platform for next generation biomanufacturing. Collaborative with Ranjan Srivastava, Dan Gage, Joerg Graf, Bill Mustain, & Ken Noll. Funding: http://www.nsf.gov/awardsearch/showAward?AWD_ID=1137249
Previous Positions
2005-2009 | Research Assistant Professor, Vanderbilt University Department of Civil & Environmental Engineering |
2002-2004 | Post-Doctoral Research Associate, Vanderbilt University Department of Civil & Environmental Engineering |
Awards & Honors
2014 | DuPont Young Professor |
2012 | Finalist, Connecticut Women of Innovation, Academic Innovation and Leadership |
2011 | National Academy of Engineering Frontiers of Engineering Education Symposium Selectee |
1996-1999 | National Institutes of Health Biotechnology Training Program Fellow |
Papers
Rubinstein, RL, AL Kadilak, VC Cousens, DJ Gage, LM Shor. 2015. Protist-facilitated particle transport using emulated soil micromodels. Environmental Science & Technology. 49(3), 1384–1391.
Deng, J, EP Orner, JF Chau, EM Anderson, AL Kadilak, RL Rubinstein, GM Bouchillon, R Goodwin, DJ Gage, LM Shor. 2015. Pore-scale determination of microbially-mediated drying resistance using emulated soil micromodels. Soil Biology & Biochemistry. 83(4), 116–124.
Bouchillon, GM, JF Chau, G. B. McManus, LM Shor. 2014. Microfluidic passive samplers for concentration and isolation of live protists. Analytical Methods. 6 (20), 8350-8357.
Kadilak, AL, Y. Liu, S Shrestha, JR Bernard, WE Mustain, LM Shor. 2014. Selective deposition of chemically-bonded gold electrodes onto PDMS microchannel side walls. J. Electroanalytical Chemistry. 727, 141-147.
Schröfel, A, G Kratošová, I Šafařík, M Šafaříková, I Raška, LM Shor. 2014. Applications of biogenic metallic nanoparticles – a review.” Acta Biomaterialia. 10 (10), 4023-4042
Deng, J, A Dhummakupt, PC Samson, JP Wikswo, LM Shor. 2013. “Dynamic dosing assay relating real-time respiration responses of Staphylococcus aureus biofilms to changing micro-chemical conditions.” Analytical Chemistry. 85 (11), 5411–19.
leslie.shor@uconn.edu | |
Phone | (860) 486-3136 |
Mailing Address | 191 Auditorium Road, Unit 3222, Storrs, CT 06269-3222 |
Office Location | Castleman Building, Rm. 224 |
Link | http://www.leslieshor.com/ |